Histidine Decarboxylase Activity in Fetal Intrauterine Growth-retarded Rats
نویسندگان
چکیده
منابع مشابه
Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats.
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in later life. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat. Early in life, the animals are insulin resistant and by 6 mo of age they develop diabetes. Glycogen content and insulin-stimulated 2-deoxyglucose uptake were significa...
متن کاملHigh sodium intake increases blood pressure and alters renal function in intrauterine growth-retarded rats.
A suboptimal fetal environment increases the risk to develop cardiovascular disease in the adult. We reported previously that intrauterine stress in response to reduced uteroplacental blood flow in the pregnant rat limits fetal growth and compromises renal development, leading to an altered renal function in the adult offspring. Here we tested the hypothesis that high dietary sodium intake in r...
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Thyrotropin-releasing hormone (TRH) acts in brain stem nuclei to induce vagally mediated stimulation of gastric secretion. The effects of intracisternal injection of the TRH analog RX-77368 on plasma gastrin levels and corpus histidine decarboxylase (HDC) activity were studied in 48-h fasted conscious rats. RX-77368 (25-100 ng) increased plasma gastrin levels by threefold at 30 min, which remai...
متن کاملEffect of hydrocortisone on histidine decarboxylase activity in rat stomach.
Hydrocortisone-stimulated synthesis of histidine decarboxylase (EC 4.1.1.22) was studied in rat stomach. Single or daily administration of hydrocortisone increased the histidine decarboxylase activity but not the histamine content in the fundic glands of stomachs from fed and fasted rats with or without adrenalectomy, and also in those from adrenalectomized fasted rats with concomitant treatmen...
متن کاملLeukocyte histidine decarboxylase: properties and activity in myeloproliferative disorders.
E ARLIER OBSERVATIONS of elevated blood and urine histamine levels in myeloproliferative disorders1’2 have recently been confirmed and extended in this laboratory using a sensitive and specific spectrophotofluorometric assay.3 Whole blood and urine histamine content was demonstrated to be increased in uncontrolled polycythemia vera, “spent” polycythemia, and myelofibrosis with myeloid metaplasi...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1976
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197608000-00008